5-Amino 1MQ Peptide: How It Works & Benefits

Written by: Billy White



Time to read 6 min

Evidence-based. Last updated: November 23, 2023

5-Amino 1MQ is an NNMT inhibitor

It promotes weight loss, muscle growth, cellular energy, and NAD+

It's commonly used for performance-enhancing and anti-aging, it may be effective for both

5-amino 1MQ is a small, selective, membrane-permeable molecule.


Its ability to selectively inhibit the enzyme nicotinamide N-methyltransferase (NNMT) without affecting other metabolic enzymes makes it a promising candidate for various therapeutic applications.


It is widely known in the biohacking, PED, and peptide community.

How It Works

5-amino 1MQ (5-amino-1-methylquinolinium) works primarily by blocking NNMT (Nicotinamide N-methyltransferase), which plays a pivotal role in cellular metabolism and energy homeostasis.


By inhibiting NNMT, 5-amino 1MQ:

  • enhances fat cell metabolism

  • promotes weight loss

  • and stimulates the production of nicotinamide adenine dinucleotide (NAD+)


This action activates the sirtuin-1 (SIRT1) gene, known as the "longevity gene", due to its ability to help mitigate various age-related diseases.

5-amino 1mq mechanism of action infographic

Effects of 5-Amino 1MQ

1. Reduction in Obesity

5-amino 1MQ has shown a significant impact in reducing body fat by inhibiting NNMT, which is often overexpressed in adipose tissues of obese individuals.


This inhibition leads to an increase in NAD+ levels, enhancing the metabolic rate of fat cells.

2. Improved Insulin Sensitivity

The compound has demonstrated potential in improving insulin sensitivity.


This makes it a promising agent in managing type 2 diabetes and metabolic syndrome.

3. Improved Lipid Profile

By affecting lipid metabolism, 5-amino 1MQ helps in lowering triglycerides and cholesterol levels.


This may have the benefit of reducing the risk of cardiovascular diseases associated with obesity.

4. Enhanced Muscle Stem Cell Acitivty

5-amino 1MQ enhances the proliferation and function of satellite cells (muscle stem cells).


These are vital for muscle repair and regeneration, particularly important for aging populations and athletes.


This leads to an increase in muscle fiber size, contributing to greater muscle mass and strength.

5. Reduced Muscle Wasting

It shows potential in combating muscle wasting conditions such as sarcopenia and cachexia.


By inhibiting pathways that lead to muscle atrophy, such as those activated during prolonged inactivity or illness, 5-amino 1MQ helps in preserving muscle mass and strength.


It could help elderly individuals and people with chronic diseases.

6. Activation of Longevity Genes

By increasing NAD+ levels, 5-amino 1MQ activates SIRT1, a gene associated with longevity and resistance to age-related diseases.


This could have implications for anti-aging, neurodegenerative diseases, and overall cellular health.

7. Neuroprotective Effects

Preliminary studies suggest that 5-amino 1MQ may have neuroprotective effects.


This is potentially beneficial in conditions like Alzheimer’s disease and other forms of neurodegenerative diseases.

8. Increased Cellular Energy

By modulating NAD+ metabolism, 5-amino 1MQ plays a role in maintaining cellular energy homeostasis.


It also improves mitochondrial efficiency, which is crucial for muscle endurance.


Enhanced mitochondrial function leads to better energy utilization in muscle cells, allowing for prolonged physical activity and improved athletic performance.


The compound may also play a role in reducing muscle fatigue by optimizing energy metabolism, thereby extending the time to exhaustion during high-intensity exercises. 


This could potentially translate into better endurance and cardio performance.

9. Potential Anti-Cancer Effects

Emerging research indicates that 5-amino 1MQ may disrupt the metabolic pathways in certain types of cancer cells.

NNMT-Inhibitor Effects on Muscle Growth

5-amino 1MQ is classified as an NNMT-inhibitor.


Currently, there are no specific drugs known to regenerate muscle stem cells (also called satellite cells).


In one study, older mice were treated with different doses of an NNMT inhibitor after a muscle injury.


The study looked at how well their muscle stem cells worked by tracking cell activity and muscle healing.


The results showed that the treated mice had more active muscle stem cells, leading to larger muscle fibers and stronger muscles compared to untreated mice.


These changes happened regardless of age-related muscle loss, known as sarcopenia, which usually makes muscle stem cells less effective and less likely to be activated by injury.

Safety & Adverse Effects

5-amino 1MQ has been generally well-tolerated in the studies conducted so far.


However, the long-term safety profile is still under investigation, especially considering its impact on various metabolic pathways.


There is also limited data on the safety of this research peptide in specific populations such as pregnant or breastfeeding women, children, and those with pre-existing health conditions. 


Caution is advised and 5-amino 1MQ is not recommended for human use until more studies are completed.

Reported Adverse Effects

  • Sleep Disturbances: Some individuals have reported difficulty sleeping, which could be linked to the metabolic changes induced by 5-amino 1MQ.

  • Hypoglycaemia: There have been reports of individuals experiencing low blood sugar (hypoglycaemia) potentially induced by this peptide.

  • Digestive Discomfort: Mild gastrointestinal discomfort has been noted in some cases.

Lack of Approval

As of now, 5-amino 1MQ is not approved by the FDA, or any other health authority, for any specific medical condition, and its use is largely experimental.

Frequently Asked Questions

Is 5-amino 1mq legal?

At the time of publishing this article, it is legal and can be sold for research purposes only.

What is NNMT?

Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. It's expression is associated with cancer, obesity, and insulin resistance.

Written by: Billy White

Billy White is an experienced personal trainer, an aspiring bodybuilder, and loves to research. He's passionate about serving the fitness and health community with the highest-quality, study-backed information.


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