ACE-031 Peptide: What Is It & How Does It Work?
Time to read 3 min
Time to read 3 min
Evidence-based. Last updated: November 23, 2023
ACE-031 is a myostatin inhibitor
It promotes muscle growth and reduces atrophy signalling
It's being researched for muscle wasting conditions like Cachexia and age-related muscle loss, it may be effective for these
ACE-031, a type of myostatin inhibitor, has sparked significant interest in the medical and scientific community for its potential in muscle growth and treatment of muscle-wasting diseases.
It is a fusion protein of activin receptor type IIB and IgG1-Fc, which binds myostatin and related ligands.
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ACE-031 has various mechanisms of action, including the following.
Myostatin, a member of the transforming growth factor-beta (TGF-β) superfamily, is a critical regulator of skeletal muscle mass.
Normally, myostatin limits muscle tissue growth, ensuring that muscle size and growth are kept in check.
ACE-031 interferes with this regulation by binding to myostatin, rendering it inactive.
This results in the removal of the physiological brake on muscle growth.
ActRIIB receptors play a role in mediating the effects of myostatin as well as other ligands like activins and growth differentiation factors (GDFs).
By binding to these receptors, ACE-031 disrupts the signaling cascade that typically suppresses muscle cell growth and differentiation.
Beyond promoting muscle hypertrophy (enlargement), ACE-031 may also enhance muscle repair and regeneration.
This aspect is crucial in clinical scenarios like muscle injuries, dystrophies, or age-related muscle loss.
Following administration, ACE-031 rapidly enters the circulatory system.
It then localizes predominantly in muscle tissues, which are the primary sites of action.
ACE-031 is likely metabolized by proteolytic enzymes, similar to other peptides.
It's suggested to have a half-life of approx. 15 days.
ACE-031 is primarily explored for conditions like Duchenne Muscular Dystrophy (DMD) and other muscle-wasting diseases.
Its application could extend to age-related muscle loss (sarcopenia) and possibly to certain rehabilitation therapies post-injury.
The potential for misuse in enhancing athletic performance has raised ethical concerns.
Preliminary clinical trials have shown a relatively safe profile, but the long-term effects are not yet fully understood.
Potential side effects could include:
As of this articles last update, ACE-031 had not received approval from regulatory bodies like the FDA for clinical use.
Its use in non-therapeutic contexts, particularly in sports, raises ethical and fairness issues.
Regulatory agencies and sports governing bodies are closely monitoring its development and potential misuse.
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